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Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study.
https://s-sph.repo.nii.ac.jp/records/2000119
https://s-sph.repo.nii.ac.jp/records/2000119d015bd11-8100-4e35-9ae5-afafc1644193
| 名前 / ファイル | ライセンス | アクション |
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Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study The Shizuoka study.pdf (268 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2025-07-25 | |||||
| タイトル | ||||||
| タイトル | Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| キーワード | ||||||
| 主題Scheme | MeSH | |||||
| 主題 | Cardiovascular Diseases | |||||
| キーワード | ||||||
| 主題Scheme | MeSH | |||||
| 主題 | Obesity | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者（英） | ||||||
| 姓名 | Tabara, Yasuharu | |||||
| 姓名 | Shoji-Asahina, Aya | |||||
| 姓名 | Ogawa, Aya | |||||
| 姓名 | Sato, Yoko | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy obesity by comparing clinical profile-matched metabolically healthy obesity and non-obesity groups. METHODS: We analyzed a health insurance dataset with annual health checkup data from Japan. The analyzed data included 168,699 individuals aged <65 years. Obesity was defined as ≥25 kg/m2 body mass index. Metabolically healthy was defined as ≤1 metabolic risk factor (high blood pressure, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, or high hemoglobin A1c). Incidence rates of stroke, myocardial infarction, and all-cause mortality identified from the insurance data were compared between metabolically healthy obesity and non-obesity groups (n = 8644 each) using a log-rank test. RESULTS: The stroke (obesity: 9.2 per 10,000 person-years; non-obesity: 10.5; log-rank test p = 0.595), myocardial infarction (obesity: 3.7; non-obesity: 3.1; p = 0.613), and all-cause mortality (obesity: 26.6; non-obesity: 23.2; p = 0.304) incidence rates did not differ significantly between the metabolically healthy obesity and non-obesity groups, even when the abdominal obesity was considered in the analysis. The lack of association was also observed in the comparison between the metabolically unhealthy obesity and non-obesity groups (n = 10,965 each). The population with metabolically healthy obesity reported negligibly worse metabolic profiles than the population with non-obesity at the 5.6-year follow-up. CONCLUSION: Obesity, when accompanied by a healthy metabolic profile, did not increase the risk of cardiovascular outcomes and all-cause mortality. |
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| 言語 | en | |||||
| 書誌情報 |
International Journal of Obesity 巻 48, 号 8, p. 1164-1169 |
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| 出版者 | ||||||
| 出版者 | Nature Research | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41366-024-01541-3 | |||||
| 権利 | ||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41366-024-01541-3 | |||||
